| 1 | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC | $41,316,801,718 | 1 | $41,316,801,718 | May 09, 2007 | Department of Energy |
| 2 | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $35,295,925,219 | 1 | $35,295,925,219 | Sep 30, 1978 | Department of Energy |
| 3 | BATTELLE MEMORIAL INSTITUTE | $30,673,332,390 | 1 | $30,673,332,390 | Sep 15, 1978 | Department of Energy |
| 4 | LOCKHEED MARTIN CORP | $24,611,038,794 | 2 | $12,305,519,397 | Sep 06, 2006 | Department of Defense |
| 5 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | $19,868,865,110 | 1 | $19,868,865,110 | Jun 01, 2005 | Department of Energy |
| 6 | UCHICAGO ARGONNE, LLC | $17,420,483,635 | 1 | $17,420,483,635 | Jul 31, 2006 | Department of Energy |
| 7 | THE LELAND STANFORD JUNIOR UNIVERSITY | $15,246,687,850 | 3 | $5,082,229,283 | Oct 15, 2002 | National Aeronautics and … |
| 8 | JEFFERSON SCIENCE ASSOCIATES, LLC | $3,122,899,691 | 1 | $3,122,899,691 | Apr 17, 2006 | Department of Energy |
| 9 | ASSOCIATION OF UNIVERSITIES FOR RESEARCH IN… | $1,589,272,070 | 1 | $1,589,272,070 | Oct 01, 2003 | National Aeronautics and … |
| 10 | THE JOHNS HOPKINS UNIVERSITY APPLIED PHYSIC… | $1,438,431,941 | 11 | $130,766,540 | Nov 27, 2019 | National Aeronautics and … |
| 11 | SMITHSONIAN INSTITUTION | $1,394,857,888 | 2 | $697,428,944 | Dec 01, 2006 | National Aeronautics and … |
| 12 | IOWA STATE UNIVERSITY OF SCIENCE AND TECHNO… | $1,127,521,095 | 1 | $1,127,521,095 | Dec 04, 2006 | Department of Energy |
